diff --git a/CHANGES.rst b/CHANGES.rst
index e22b15a3..50c43307 100644
--- a/CHANGES.rst
+++ b/CHANGES.rst
@@ -17,6 +17,7 @@ New Features
   scale is computed in closed form, and the elliptical and rectangular
   annuli convert both of their shapes with one WCS evaluation in each
   direction. [#707]
+- Add serialization of regions to ASDF files. [#702]
 
 Bug Fixes
 ---------
diff --git a/pyproject.toml b/pyproject.toml
index e2286a61..1dc70083 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -27,6 +27,7 @@ requires-python = '>=3.11'
 dependencies = [
     'astropy >= 7.0',
     'numpy >= 2.0',
+    'asdf',
 ]
 
 [project.urls]
@@ -39,6 +40,7 @@ all = [
     'shapely >= 2.1',
 ]
 test = [
+    'pytest-asdf-plugin',
     'gwcs >= 0.22',
     'pytest-arraydiff >= 0.6.1',
     'pytest-astropy >= 0.12',
@@ -80,9 +82,13 @@ include-package-data = false
 namespaces = false
 
 [tool.setuptools.package-data]
+'regions.io.asdf.resources' = [
+    '**/*.yaml'
+]
 '*' = [
     'data/*',
 ]
+
 'regions.shapes.tests' = [
     'reference/*.txt',
     'data/*.fits',
@@ -97,6 +103,11 @@ namespaces = false
     'data/*.fits',
 ]
 
+
+[project.entry-points]
+'asdf.extensions' = {regions = 'regions.io.asdf.extension:get_extensions'}
+'asdf.resource_mappings' = {regions = 'regions.io.asdf.extension:get_resource_mappings'}
+
 [tool.pytest.ini_options]
 minversion = "8.0"
 testpaths = [
@@ -117,6 +128,9 @@ addopts = [
     '--strict-config',
     '--strict-markers',
 ]
+asdf_schema_root = 'regions/io/asdf/resources/schemas'
+asdf_schema_tests_enabled = true
+
 log_level = 'INFO'
 log_cli_level = 'INFO'
 xfail_strict = true
@@ -142,6 +156,7 @@ omit = [
     '*/regions/*/tests/*',
     '*/regions/extern/*',
     '*/regions/version*',
+    'regions/io/asdf/converters/tests/*',
 ]
 
 [tool.coverage.report]
@@ -224,6 +239,8 @@ exclude = [
     '\._.*',  # private functions/methods
     '^test_*',  # test code
     '^conftest.*$',  # pytest configuration
+    'to_yaml_tree',  # ASDF converter
+    'from_yaml_tree',  # ASDF converter
 ]
 
 [tool.ruff]
diff --git a/regions/io/__init__.py b/regions/io/__init__.py
index c58b0dbd..d361cd42 100644
--- a/regions/io/__init__.py
+++ b/regions/io/__init__.py
@@ -15,3 +15,4 @@
 from .fits.core import *  # noqa: F401, F403
 from .fits.read import *  # noqa: F401, F403
 from .fits.write import *  # noqa: F401, F403
+from .asdf import extension  # noqa: F401
diff --git a/regions/io/asdf/__init__.py b/regions/io/asdf/__init__.py
new file mode 100644
index 00000000..e69de29b
diff --git a/regions/io/asdf/converters/__init__.py b/regions/io/asdf/converters/__init__.py
new file mode 100644
index 00000000..c2f7e2a5
--- /dev/null
+++ b/regions/io/asdf/converters/__init__.py
@@ -0,0 +1,10 @@
+# Licensed under a 3-clause BSD style license - see LICENSE.rst
+"""
+ASDF converters.
+"""
+
+from .pixel_coords import PixCoordConverter
+
+__all__ = [
+    'PixCoordConverter',
+]
diff --git a/regions/io/asdf/converters/pixel_coords.py b/regions/io/asdf/converters/pixel_coords.py
new file mode 100644
index 00000000..81818a5e
--- /dev/null
+++ b/regions/io/asdf/converters/pixel_coords.py
@@ -0,0 +1,33 @@
+# Licensed under a 3-clause BSD style license - see LICENSE.rst
+
+"""
+ASDF converter for PixCoord object.
+"""
+from asdf.extension import Converter
+
+__all__ = [
+    'PixCoordConverter',
+]
+
+
+class PixCoordConverter(Converter):
+    """
+    ASDF converter for pixel coordinates.
+    """
+
+    tags = ('tag:astropy.org:regions/pixcoord-*',)
+    types = ('regions.core.pixcoord.PixCoord',)
+
+    def to_yaml_tree(self, obj, tag, ctx):  # noqa: ARG002
+
+        return {
+            'x': obj.x,
+            'y': obj.y,
+        }
+
+    def from_yaml_tree(self, node, tag, ctx):  # noqa: ARG002
+        from regions.core.pixcoord import PixCoord
+        return PixCoord(
+            x=node['x'],
+            y=node['y'],
+        )
diff --git a/regions/io/asdf/converters/tests/__init__.py b/regions/io/asdf/converters/tests/__init__.py
new file mode 100644
index 00000000..e69de29b
diff --git a/regions/io/asdf/converters/tests/conftest.py b/regions/io/asdf/converters/tests/conftest.py
new file mode 100644
index 00000000..7325137e
--- /dev/null
+++ b/regions/io/asdf/converters/tests/conftest.py
@@ -0,0 +1,21 @@
+# Licensed under a 3-clause BSD style license - see LICENSE.rst
+
+import pytest
+
+from regions.io.asdf.converters.tests import examples
+
+
+@pytest.fixture
+def test_pixcoord():
+    """
+    Test that PixCoord can be serialized and deserialized correctly.
+    """
+    return examples.pixcoord()
+
+
+@pytest.fixture
+def test_pixcoord_array():
+    """
+    Test that PixCoord can be serialized and deserialized correctly.
+    """
+    return examples.pixcoord_array()
diff --git a/regions/io/asdf/converters/tests/examples.py b/regions/io/asdf/converters/tests/examples.py
new file mode 100644
index 00000000..b37d8cc1
--- /dev/null
+++ b/regions/io/asdf/converters/tests/examples.py
@@ -0,0 +1,16 @@
+# Licensed under a 3-clause BSD style license - see LICENSE.rst
+import numpy as np
+
+from regions.core import PixCoord
+
+parameters = {
+    'PixCoord': ['x', 'y'],
+}
+
+
+def pixcoord():
+    return PixCoord(1, 2), parameters['PixCoord']
+
+
+def pixcoord_array():
+    return PixCoord(np.array([1, 2]), np.array([3, 4])), parameters['PixCoord']
diff --git a/regions/io/asdf/converters/tests/test.py b/regions/io/asdf/converters/tests/test.py
new file mode 100644
index 00000000..244c320a
--- /dev/null
+++ b/regions/io/asdf/converters/tests/test.py
@@ -0,0 +1,37 @@
+# Licensed under a 3-clause BSD style license - see LICENSE.rst
+
+import asdf
+import pytest
+from numpy.testing import assert_array_equal
+
+
+@pytest.fixture
+def obj(request):
+    """
+    A pytest fixture that returns a 'Region' instance and the
+    list of parameters to test.
+    """
+    return request.getfixturevalue(request.param)
+
+
+region_params = pytest.mark.parametrize('obj', [
+    'test_pixcoord',
+    'test_pixcoord_array',
+], indirect=True)
+
+
+@region_params
+def test_region_converters(tmp_path, obj):
+    """
+    Test that the Region converters can round-trip a Region object.
+    """
+    region, pars = obj
+    with asdf.AsdfFile() as af:
+        af['region'] = region
+        af.write_to(tmp_path / 'region.asdf')
+
+        with asdf.open(tmp_path / 'region.asdf') as af:
+            region2 = af['region']
+            for parameter in pars:
+                assert_array_equal(getattr(region, parameter),
+                                   getattr(region2, parameter))
diff --git a/regions/io/asdf/extension.py b/regions/io/asdf/extension.py
new file mode 100644
index 00000000..d52afa7a
--- /dev/null
+++ b/regions/io/asdf/extension.py
@@ -0,0 +1,66 @@
+# Licensed under a 3-clause BSD style license - see LICENSE.rst
+"""
+ASDF extension for regions.
+"""
+import importlib.resources as importlib_resources
+
+from asdf.extension import ManifestExtension
+from asdf.resource import DirectoryResourceMapping
+
+from regions.io.asdf.converters.pixel_coords import PixCoordConverter
+
+__all__ = ['PixCoordConverter']
+
+
+REGIONS_CONVERTERS = [
+    PixCoordConverter(),
+]
+
+# The order here is important; asdf will prefer to use extensions
+# that occur earlier in the list.
+REGIONS_MANIFEST_URIS = [
+    'asdf://astropy.org/regions/manifests/regions-1.0.0',
+]
+
+
+def get_extensions():
+    """
+    Get the regions extension.
+    This method is registered with the asdf.extensions entry point.
+
+    Returns
+    -------
+    list
+        A list of ASDF extensions.
+    """
+    return [
+        ManifestExtension.from_uri(
+            uri,
+            converters=REGIONS_CONVERTERS,
+        )
+        for uri in REGIONS_MANIFEST_URIS
+    ]
+
+
+def get_resource_mappings():
+    """
+    Get the resource mapping instances for the regions schemas
+    and manifests.  This method is registered with the
+    asdf.resource_mappings entry point.
+
+    Returns
+    -------
+    list
+        A list of collections.abc.Mapping of ASDF resource mappings.
+    """
+    from regions.io.asdf import resources
+
+    resources_root = importlib_resources.files(resources)
+
+    return [
+        DirectoryResourceMapping(resources_root / 'schemas',
+                                 'asdf://astropy.org/regions/schemas',
+                                 recursive=True),
+        DirectoryResourceMapping(resources_root / 'manifests',
+                                 'asdf://astropy.org/regions/manifests'),
+    ]
diff --git a/regions/io/asdf/resources/__init__.py b/regions/io/asdf/resources/__init__.py
new file mode 100644
index 00000000..e69de29b
diff --git a/regions/io/asdf/resources/manifests/regions-1.0.0.yaml b/regions/io/asdf/resources/manifests/regions-1.0.0.yaml
new file mode 100644
index 00000000..f5f3dc9e
--- /dev/null
+++ b/regions/io/asdf/resources/manifests/regions-1.0.0.yaml
@@ -0,0 +1,10 @@
+id: asdf://astropy.org/regions/manifests/regions-1.0.0
+extension_uri: asdf://astropy.org/regions/extensions/regions-1.0.0
+title: Regions extension 1.0.0
+description: |-
+  A set of tags for serializing astropy regions objects.
+tags:
+  - tag_uri: tag:astropy.org:regions/pixcoord-1.0.0
+    schema_uri: asdf://astropy.org/regions/schemas/pixcoord-1.0.0
+    title: PixCoord schema
+    description: Pixel coordinates for regions.
diff --git a/regions/io/asdf/resources/schemas/pixcoord-1.0.0.yaml b/regions/io/asdf/resources/schemas/pixcoord-1.0.0.yaml
new file mode 100644
index 00000000..9117cb8a
--- /dev/null
+++ b/regions/io/asdf/resources/schemas/pixcoord-1.0.0.yaml
@@ -0,0 +1,33 @@
+%YAML 1.1
+---
+$schema: 'http://stsci.edu/schemas/yaml-schema/draft-01'
+id: 'asdf://astropy.org/regions/schemas/pixcoord-1.0.0'
+title: Pixel coordinates
+description: |
+  ASDF schema for serializing a pixel coordinate.
+
+examples:
+  - - A 'PixCoord' object with x=1.0 and y=2.0
+    - |
+      !<tag:astropy.org:regions/pixcoord-1.0.0%22> {x: 1, y: 2}
+
+type: object
+properties:
+  x:
+    title: X coordinate.
+    anyOf:
+      - type: number
+      - type: array
+      - tag: 'tag:stsci.edu:asdf/core/ndarray-1.*'
+    description: |
+      The x coordinate of the pixel.
+  y:
+    title: Y coordinate.
+    anyOf:
+      - type: number
+      - type: array
+      - tag: 'tag:stsci.edu:asdf/core/ndarray-1.*'
+    description: |
+      The y coordinate of the pixel.
+required: [x, y]
+...