diff --git a/.changeset/tanstack-query-plugin-reload-sync.md b/.changeset/tanstack-query-plugin-reload-sync.md
new file mode 100644
index 00000000..72272c0b
--- /dev/null
+++ b/.changeset/tanstack-query-plugin-reload-sync.md
@@ -0,0 +1,8 @@
+---
+'@rozenite/tanstack-query-plugin': patch
+---
+
+Fix the TanStack Query panel staying empty after an app reload. The device now
+announces itself once it is listening, so the panel pulls the cache again
+instead of waiting forever on a request that was sent before the app finished
+mounting.
diff --git a/packages/tanstack-query-plugin/src/react-native/useHandleInitialData.ts b/packages/tanstack-query-plugin/src/react-native/useHandleInitialData.ts
index 4b34ceec..925bff77 100644
--- a/packages/tanstack-query-plugin/src/react-native/useHandleInitialData.ts
+++ b/packages/tanstack-query-plugin/src/react-native/useHandleInitialData.ts
@@ -17,6 +17,13 @@ export const useHandleInitialData = (
       client.send('sync-data', { data: dehydratedState });
     });
 
+    // This hook runs last in `useTanStackQueryDevTools`, so by the time the
+    // panel reacts to this every handler is listening. The panel is recreated on
+    // every app reload and asks for the cache as soon as it boots, which usually
+    // beats the app's React tree to the punch; without this its only request is
+    // dropped and the panel stays empty until the app is restarted.
+    client.send('device-ready', {});
+
     return () => {
       subscription.remove();
     };
diff --git a/packages/tanstack-query-plugin/src/shared/messaging.ts b/packages/tanstack-query-plugin/src/shared/messaging.ts
index a00b4ffa..dd5efb01 100644
--- a/packages/tanstack-query-plugin/src/shared/messaging.ts
+++ b/packages/tanstack-query-plugin/src/shared/messaging.ts
@@ -19,6 +19,13 @@ export type TanStackQueryPluginEventMap = {
       data?: unknown;
     };
   };
+  /**
+   * Announced by the device once it is listening for panel messages. The panel
+   * is recreated on every app reload and asks for the cache immediately, which
+   * can land before the app's React tree has mounted the plugin; this lets the
+   * panel ask again instead of staying empty until the app is restarted.
+   */
+  'device-ready': unknown;
   'request-initial-data': unknown;
   'sync-data': {
     data: SerializableQueryClient;
diff --git a/packages/tanstack-query-plugin/src/ui/useSyncInitialData.test.tsx b/packages/tanstack-query-plugin/src/ui/useSyncInitialData.test.tsx
new file mode 100644
index 00000000..01aeca9d
--- /dev/null
+++ b/packages/tanstack-query-plugin/src/ui/useSyncInitialData.test.tsx
@@ -0,0 +1,76 @@
+// @vitest-environment jsdom
+
+import { act, type ReactNode } from 'react';
+import { createRoot } from 'react-dom/client';
+import { QueryClient, QueryClientProvider } from '@tanstack/react-query';
+import { afterEach, beforeEach, describe, expect, it, vi } from 'vitest';
+import { TanStackQueryPluginClient } from '../shared/messaging';
+import { useSyncInitialData } from './useSyncInitialData';
+
+declare global {
+  var IS_REACT_ACT_ENVIRONMENT: boolean | undefined;
+}
+
+type Listener = (payload: unknown) => void;
+
+const createClient = () => {
+  const listeners = new Map<string, Set<Listener>>();
+
+  return {
+    send: vi.fn(),
+    onMessage: vi.fn((type: string, listener: Listener) => {
+      const typeListeners = listeners.get(type) ?? new Set<Listener>();
+      typeListeners.add(listener);
+      listeners.set(type, typeListeners);
+      return { remove: () => typeListeners.delete(listener) };
+    }),
+    close: vi.fn(),
+    emit: (type: string, payload: unknown) =>
+      listeners.get(type)?.forEach((listener) => listener(payload)),
+  };
+};
+
+const requests = (client: ReturnType<typeof createClient>) =>
+  client.send.mock.calls.filter(([type]) => type === 'request-initial-data');
+
+describe('useSyncInitialData', () => {
+  beforeEach(() => {
+    globalThis.IS_REACT_ACT_ENVIRONMENT = true;
+  });
+  afterEach(() => {
+    document.body.innerHTML = '';
+    delete globalThis.IS_REACT_ACT_ENVIRONMENT;
+  });
+
+  // The panel is recreated on every app reload and asks for the cache before the
+  // app's React tree has mounted the plugin, so its first request is dropped.
+  it('asks for the cache again when the device announces itself', async () => {
+    const client = createClient();
+    const queryClient = new QueryClient();
+    queryClient.setQueryData(['stale-from-previous-context'], 'value');
+
+    const Harness = ({ children }: { children?: ReactNode }) => {
+      useSyncInitialData(client as unknown as TanStackQueryPluginClient);
+      return <>{children}</>;
+    };
+    const container = document.createElement('div');
+    document.body.append(container);
+    const root = createRoot(container);
+    await act(async () =>
+      root.render(
+        <QueryClientProvider client={queryClient}>
+          <Harness />
+        </QueryClientProvider>,
+      ),
+    );
+
+    expect(requests(client)).toHaveLength(1);
+
+    await act(async () => client.emit('device-ready', {}));
+
+    expect(requests(client)).toHaveLength(2);
+    expect(queryClient.getQueryData(['stale-from-previous-context'])).toBeUndefined();
+
+    await act(async () => root.unmount());
+  });
+});
diff --git a/packages/tanstack-query-plugin/src/ui/useSyncInitialData.ts b/packages/tanstack-query-plugin/src/ui/useSyncInitialData.ts
index ea8f5f51..dc4f0972 100644
--- a/packages/tanstack-query-plugin/src/ui/useSyncInitialData.ts
+++ b/packages/tanstack-query-plugin/src/ui/useSyncInitialData.ts
@@ -1,12 +1,27 @@
 import { useEffect } from 'react';
+import { useQueryClient } from '@tanstack/react-query';
 import { TanStackQueryPluginClient } from '../shared/messaging';
 
 export const useSyncInitialData = (client: TanStackQueryPluginClient | null) => {
+  const queryClient = useQueryClient();
+
   useEffect(() => {
     if (!client) {
       return;
     }
 
+    // The device announces itself once it is listening. It reconnects on every
+    // app reload, so the cache has to be pulled again — what the panel holds
+    // belongs to the previous JS context.
+    const subscription = client.onMessage('device-ready', () => {
+      queryClient.clear();
+      client.send('request-initial-data', {});
+    });
+
     client.send('request-initial-data', {});
-  }, [client]);
+
+    return () => {
+      subscription.remove();
+    };
+  }, [client, queryClient]);
 };