diff --git a/resources/python/bin/3.10/explicit_requirements.txt b/resources/python/bin/3.10/explicit_requirements.txt
index 16bc8dba3..88e3ef9a8 100644
--- a/resources/python/bin/3.10/explicit_requirements.txt
+++ b/resources/python/bin/3.10/explicit_requirements.txt
@@ -9,5 +9,5 @@
 # agreement to the Shotgun Pipeline Toolkit Source Code License. All rights
 # not expressly granted therein are reserved by Shotgun Software Inc.
 cffi==2.0.0
-cryptography==46.0.7
+cryptography==50.0.0
 zope.interface==8.3
diff --git a/resources/python/bin/3.11/explicit_requirements.txt b/resources/python/bin/3.11/explicit_requirements.txt
index 16bc8dba3..88e3ef9a8 100644
--- a/resources/python/bin/3.11/explicit_requirements.txt
+++ b/resources/python/bin/3.11/explicit_requirements.txt
@@ -9,5 +9,5 @@
 # agreement to the Shotgun Pipeline Toolkit Source Code License. All rights
 # not expressly granted therein are reserved by Shotgun Software Inc.
 cffi==2.0.0
-cryptography==46.0.7
+cryptography==50.0.0
 zope.interface==8.3
diff --git a/resources/python/bin/3.13/explicit_requirements.txt b/resources/python/bin/3.13/explicit_requirements.txt
index 16bc8dba3..88e3ef9a8 100644
--- a/resources/python/bin/3.13/explicit_requirements.txt
+++ b/resources/python/bin/3.13/explicit_requirements.txt
@@ -9,5 +9,5 @@
 # agreement to the Shotgun Pipeline Toolkit Source Code License. All rights
 # not expressly granted therein are reserved by Shotgun Software Inc.
 cffi==2.0.0
-cryptography==46.0.7
+cryptography==50.0.0
 zope.interface==8.3
diff --git a/resources/python/bin/3.9/explicit_requirements.txt b/resources/python/bin/3.9/explicit_requirements.txt
index daade2154..b422391b7 100644
--- a/resources/python/bin/3.9/explicit_requirements.txt
+++ b/resources/python/bin/3.9/explicit_requirements.txt
@@ -9,5 +9,5 @@
 # agreement to the Shotgun Pipeline Toolkit Source Code License. All rights
 # not expressly granted therein are reserved by Shotgun Software Inc.
 cffi==2.0.0
-cryptography==46.0.7
+cryptography==50.0.0
 zope.interface==8.0.1