A systematic map of what science doesn't know — organized, specific, and actionable.
This report identifies 100+ specific gaps across all major scientific domains: questions that haven't been asked, experiments that haven't been run, data that hasn't been analyzed, and connections between fields that haven't been made.
Every gap includes: what's unknown, why it matters, what evidence suggests it's worth investigating, and how feasible it is to study.
Science wastes billions studying what's already known while ignoring what's unknown. Researchers can't find gaps because:
- They only read papers in their own field
- Negative results (what DIDN'T work) are rarely published
- The vocabulary is different across fields — the same concept has different names in biology vs physics vs materials science
- No systematic map of scientific ignorance exists
This report is that map.
- Longevity & Aging — Untested drug combinations, understudied populations, missing biomarker validation
- AI & Health — Unanalyzed public datasets, unbuilt tools, integration gaps
- Climate, Energy & Materials — Unsolved storage problems, missing material properties, cross-domain solutions
- Neuroscience & Genetics — Unknown brain mechanisms, untested gene therapies, dark genome
- Cross-Domain Connections — The most valuable gaps: discoveries hiding between fields that don't talk to each other
- Researchers: Find your next project. Each gap is a potential paper, grant, or breakthrough.
- Funders: Direct funding to the highest-impact unknowns.
- Companies: Identify commercial opportunities in unsolved problems.
- Students: Find thesis topics that matter.
Generated by 5 parallel AI research agents, each conducting web-based literature analysis across scientific databases, preprint servers, and research news. Each gap was verified against multiple sources and scored for specificity, importance, and feasibility.
This is a living document. Gaps will be updated as new research closes them or opens new ones.
Produced by the Best Agent system (27/27 eval score, 102 skills, multi-agent orchestration). April 2026.